MYOCARDIAL DIGOXIN UPTAKE: DISSOCIATION BETWEEN DIGITALIS-INDUCED INOTROPISM AND MYOCARDIAL LOSS OF POTASSIUM
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چکیده
منابع مشابه
Influence of extracellular potassium concentration on myocardial uptake and inotropic effect of tritiated digoxin.
Because of conflicting reports on the influence of extracellular potassium concentration ([K]o) on the inotropic action of cardiac glycosides, we compared the effects of varying [K]o (1.5, 4.5, and 7.5mM) on the inotropic action and myocardial concentration of tritiated digoxin (5 X 10~M) using the isolated cat papillary muscle. The time course of the inotropic response to digoxin was significa...
متن کاملInfluence of Potassium Depletion on Myocardial Concentration of Tritlated Digoxin
The influence of potassium deficiency on myocardial H-digoxin concentration in the mouse was studied. Tritiated digoxin, 400 /Ag/kg, was injected intraperitoneally into mice, which were killed at varying time intervals, and the "H-digoxin was extracted. One-half of the mice were made potassium deficient by a diet free of potassium. In control animals, myocardial H-digoxin was maximal by 30 min ...
متن کاملInfluence of potassium depletion on myocardial concentration of tritiated digoxin.
The influence of potassium deficiency on myocardial H-digoxin concentration in the mouse was studied. Tritiated digoxin, 400 /Ag/kg, was injected intraperitoneally into mice, which were killed at varying time intervals, and the "H-digoxin was extracted. One-half of the mice were made potassium deficient by a diet free of potassium. In control animals, myocardial H-digoxin was maximal by 30 min ...
متن کاملPotassium depletion improves myocardial potassium uptake in vivo.
Potassium depletion (KD) is a very common clinical entity often associated with adverse cardiac effects. KD is generally considered to reduce muscular Na-K-ATPase density and secondarily reduce K uptake capacity. In KD rats we evaluated myocardial Na-K-ATPase density, ion content, and myocardial K reuptake. KD for 2 wk reduced plasma K to 1.8 +/- 0.1 vs. 3.5 +/- 0.2 mM in controls (P < 0.01, n ...
متن کاملESTIMATION OF POTASSIUM, CALCIUM, AND MAGNESIUM IN BLOOD AND MYOCARDIAL TISSUE, AND DIAGNOSTIC IMPORTANCE OF URINARY MAGNESIUM EXCRETION IN EXPERIMENTALLY-INDUCED MYOCARDIAL INJURY
The results obtained in the present investigations point to a definite correlation between the onset of myocardial injury, electrocardiographic changes and biochemical changes. Changes in the electrocardiogram and elevated serum levels were paralleled by an increased excretion of magnesium in urine as early as one hour. Serum calcium and serum potassium levels did not show any significant ...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1976
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1976.tb10394.x